Targeted projection pursuit for visualizing gene expression data classifications

Faith, Joe, Mintram, Robert and Angelova, Maia (2006) Targeted projection pursuit for visualizing gene expression data classifications. Bioinformatics, 22 (21). pp. 2667-2673. ISSN 1367-4803

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Official URL: http://dx.doi.org/10.1093/bioinformatics/btl463

Abstract

We present a novel method for finding low-dimensional views of high-dimensional data: Targeted Projection Pursuit. The method proceeds by finding projections of the data that best approximate a target view. Two versions of the method are introduced; one version based on Procrustes analysis and one based on an artificial neural network. These versions are capable of finding orthogonal or non-orthogonal projections, respectively. The method is quantitatively and qualitatively compared with other dimension reduction techniques. It is shown to find 2D views that display the classification of cancers from gene expression data with a visual separation equal to, or better than, existing dimension reduction techniques.

Item Type: Article
Subjects: G600 Software Engineering
G700 Artificial Intelligence
Department: Faculties > Engineering and Environment > Mathematics, Physics and Electrical Engineering
Depositing User: Sarah Howells
Date Deposited: 10 Dec 2012 14:04
Last Modified: 10 Aug 2015 11:34
URI: http://nrl.northumbria.ac.uk/id/eprint/10588

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