Glucose enhancement of recognition memory: Differential effects on effortful processing but not aspects of ‘remember-know’ responses

Scholey, Andrew, MacPherson, Helen, Sünram-Lea, Sandra, Elliott, Jade, Stough, Con and Kennedy, David (2013) Glucose enhancement of recognition memory: Differential effects on effortful processing but not aspects of ‘remember-know’ responses. Neuropharmacology, 64. pp. 544-549. ISSN 0028-3908

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Official URL: http://dx.doi.org/10.1016/j.neuropharm.2012.06.030

Abstract

The administration of a glucose drink has been shown to enhance cognitive performance with effect sizes comparable with those from pharmaceutical interventions in human trials. In the memory domain, it is currently debated whether glucose facilitation of performance is due to differential targeting of hippocampal memory or whether task effort is a more important determinant. Using a placebo-controlled, double-blind, crossover 2(Drink: glucose/placebo) × 2(Effort: ± secondary task) design, 20 healthy young adults' recognition memory performance was measured using the ‘remember-know’ procedure. Two high effort conditions (one for each drink) included secondary hand movements during word presentation. A 25 g glucose or 30 mg saccharine (placebo) drink was consumed 10 min prior to the task. The presence of a secondary task resulted in a global impairment of memory function. There were significant Drink × Effort interactions for overall memory accuracy but no differential effects for ‘remember’ or ‘know’ responses. These data suggest that, in some circumstances, task effort may be a more important determinant of the glucose facilitation of memory effect than hippocampal mediation.

Item Type: Article
Uncontrolled Keywords: glucose, recognition memory, recollection, familiarity, mental effort, hippocampus
Subjects: C800 Psychology
Department: Faculties > Health and Life Sciences > School of Life Sciences > Psychology
Depositing User: Ellen Cole
Date Deposited: 12 Dec 2012 15:02
Last Modified: 10 Aug 2015 11:33
URI: http://nrl.northumbria.ac.uk/id/eprint/10750

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