Synthesis of β-Amino alcohols via the reduction of lactamides derived from Ethyl (2S)-Lactate with Borane-Methyl Sulfide

Lewis, Frank, Eichler, Matthias C. and Grayson, David (2009) Synthesis of β-Amino alcohols via the reduction of lactamides derived from Ethyl (2S)-Lactate with Borane-Methyl Sulfide. Synlett, 12. pp. 1923-1928. ISSN 0936-5214

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Official URL: http://dx.doi.org/10.1055/s-0029-1217538

Abstract

Reactions of ethyl (2S)-lactate with various amines affords lactamides that are reduced with borane-methyl sulfide in the presence of boron trifluoride etherate to generate enantiomerically pure β-amino alcohols in good yield.

Item Type: Article
Subjects: F100 Chemistry
Department: Faculties > Health and Life Sciences > School of Life Sciences > Applied Sciences
Depositing User: Frank Lewis
Date Deposited: 21 Dec 2012 15:50
Last Modified: 26 May 2017 22:07
URI: http://nrl.northumbria.ac.uk/id/eprint/10877

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