Iron-catalyzed cross-coupling between 1-Bromoalkynes and Grignard-derived organocuprate reagents

Castagnolo, Daniele and Botta, Maurizio (2010) Iron-catalyzed cross-coupling between 1-Bromoalkynes and Grignard-derived organocuprate reagents. European Journal of Organic Chemistry, 2010 (17). pp. 3224-3228. ISSN 1434-193X

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Official URL: http://dx.doi.org/10.1002/ejoc.201000393

Abstract

An efficient iron-catalyzed cross-coupling reaction between alkynyl bromides and Grignard-derived organocuprates has been developed. A series of alkynylarenes were successfully synthesised by starting from different 1-bromoalkynes and Grignard reagents. The methodology was successfully used for the two-step stereoselective synthesis of combretastatins and represents a valid alternative to the classical syntheses of alkynylarenes

Item Type: Article
Uncontrolled Keywords: alkynes, Iron, Grignard reagents, homogeneous catalysis
Subjects: F100 Chemistry
Department: Faculties > Health and Life Sciences > School of Life Sciences > Applied Sciences
Depositing User: Linda Barlow
Date Deposited: 09 Jan 2013 09:43
Last Modified: 10 Aug 2015 11:42
URI: http://nrl.northumbria.ac.uk/id/eprint/10978

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