Macrocyclization of Di-Boc-guanidino-alkylamines Related to Guazatine Components: Discovery and synthesis of innovative macrocyclic amidinoureas

Castagnolo, Daniele, Raffi, Francesco, Giorgi, Gianluca and Botta, Maurizio (2009) Macrocyclization of Di-Boc-guanidino-alkylamines Related to Guazatine Components: Discovery and synthesis of innovative macrocyclic amidinoureas. European Journal of Organic Chemistry, 2009 (3). pp. 334-337. ISSN 1434-193X

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Official URL: http://dx.doi.org/10.1002/ejoc.200801109

Abstract

The synthesis of new and innovative macrocyclic amidinoureas from linear di-Boc-guanidino-alkylamines related to guazatine was accomplished. The macrocyclization reaction proceeds under mild conditions affording 11- to 16-membered rings with a new and previously undescribed structure in good yields. Enantiomerically pure macrocyclic amidinoureas were also synthesised. The strict correlation between macrocyclic amidinoureas and the natural productguazatine makes them very actractive also from a biological point of view.

Item Type: Article
Uncontrolled Keywords: macrocyclization,amidino┬Čurea,aminoguanidine
Subjects: F100 Chemistry
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: Linda Barlow
Date Deposited: 09 Jan 2013 10:42
Last Modified: 24 Oct 2017 11:26
URI: http://nrl.northumbria.ac.uk/id/eprint/10979

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