Domino alkylation-cyclization reaction of propargyl bromides with thioureas/thiopyrimidinones: A new facile synthesis of 2-aminothiazoles and 5H-thiazolo[3,2-a]pyrimidin-5-ones

Botta, Maurizio, Castagnolo, Daniele, Pagano, Mafalda and Bernardini, Martina (2009) Domino alkylation-cyclization reaction of propargyl bromides with thioureas/thiopyrimidinones: A new facile synthesis of 2-aminothiazoles and 5H-thiazolo[3,2-a]pyrimidin-5-ones. Synlett, 2009 (13). pp. 2093-2096. ISSN 0936-5214

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Official URL: http://dx.doi.org/10.1055/s-0029-1217700

Abstract

A new synthesis of 2-aminothiazoles and 5H-thiazolo[3,2-a]pyrimidin-5-ones was developed as a domino alkylation-cyclization reaction of propargyl bromides with thioureas and thio¬pyrimidinones, respectively. Domino reactions were performed under microwave irradiation leading to desired compounds in a few minutes and high yields

Item Type: Article
Uncontrolled Keywords: domino reaction, 2-aminothiazole, thiazolopyrimidinone, microwave synthesis, antiviral agents
Subjects: F100 Chemistry
Department: Faculties > Health and Life Sciences > School of Life Sciences > Applied Sciences
Depositing User: Linda Barlow
Date Deposited: 09 Jan 2013 10:31
Last Modified: 12 May 2017 16:23
URI: http://nrl.northumbria.ac.uk/id/eprint/10985

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