A proteomic investigation of Streptococcus agalactiae reveals that human serum induces the C protein β antigen and arginine deiminase

Yang, Qian, Zhang, Meng, Harrington, Dean, Black, Gary and Sutcliffe, Iain (2011) A proteomic investigation of Streptococcus agalactiae reveals that human serum induces the C protein β antigen and arginine deiminase. Microbes and Infection, 13 (8-9). pp. 757-760. ISSN 1286-4579

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Official URL: http://dx.doi.org/10.1016/j.micinf.2011.03.001

Abstract

Streptococcus agalactiae is a major neonatal pathogen. Disease progression is characterised by bacterial adaptation from commensal maternal vaginal colonisation to environments associated with neonatal disease, including exposure to blood. To explore this adaptation in vitro, we have used proteomics to identify proteins differentially expressed following growth on Todd Hewitt agar in the presence or absence of 10% v/v human serum. Twelve differentially expressed proteins were identified. Notably, the C protein β antigen and arginine deiminase proteins were upregulated following growth in the presence of human serum, consistent with previous studies implicating these two proteins in the pathogenesis of S. agalactiae disease.

Item Type: Article
Uncontrolled Keywords: C protein Beta antigen, colonisation, group B Streptococcus, proteomics, sepsis, virulence factors
Subjects: B900 Others in Subjects allied to Medicine
C100 Biology
F100 Chemistry
Department: Faculties > Health and Life Sciences > School of Life Sciences > Applied Sciences
Depositing User: EPrints Services
Date Deposited: 12 Oct 2011 10:45
Last Modified: 10 Aug 2015 11:38
URI: http://nrl.northumbria.ac.uk/id/eprint/1129

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