Prevalence and molecular characterization of Enterobacteriaceae producing NDM-1 carbapenemase at a military hospital in Pakistan and evaluation of two chromogenic media

Day, Kathryn, Ali, Shamshad, Ali Mirza, Irfin, Sidjabat, Hanna, Silvey, Anna, Lanyon, Clare, Cummings, Stephen, Abbasi, Shahid, Raza, Muhammad, Paterson, David and Perry, John (2013) Prevalence and molecular characterization of Enterobacteriaceae producing NDM-1 carbapenemase at a military hospital in Pakistan and evaluation of two chromogenic media. Diagnostic Microbiology and Infectious Disease, 75 (2). pp. 187-191. ISSN 0732-8893

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Official URL: http://dx.doi.org/10.1016/j.diagmicrobio.2012.11.0...

Abstract

The aim of this study was to assess the frequency and genotypic diversity of carbapenemase-producing
Enterobacteriaceae (CPE) in stool samples from patients attending a military hospital in Pakistan. Further aims included the identification of factors that might predispose to faecal carriage and evaluation of 2 chromogenic culture media: Brilliance CRE and chromID CARBA. Of 175 patients, 32 (18.3%) had faecal carriage of CPE and all produced NDM-1 carbapenemase. All of these 32 patients were detected using chromID CARBA compared with 20 patients (62.5%) detected using Brilliance CRE (P = 0.0015). Duration of hospitalization and treatment with coamoxyclav were statistically associated with a higher likelihood of carriage of CPE (P ≤ 0.05). Themajority of NDM-1–producing Enterobacteriaceae co-produced CTX-M-1 group extended spectrum β-lactamase, and one third produced armA-type methylase. NDM-1 carbapenemase was most commonly found amongst commensal types of Escherichia coli, especially phylogenetic group B1.

Item Type: Article
Uncontrolled Keywords: carbapenemase, β-Lactamase, enterobacteriaceae, antimicrobial resistance
Subjects: A100 Pre-clinical Medicine
C500 Microbiology
Department: Faculties > Health and Life Sciences > Applied Sciences
Related URLs:
Depositing User: Stephen Cummings
Date Deposited: 26 Mar 2013 16:35
Last Modified: 24 Oct 2017 11:25
URI: http://nrl.northumbria.ac.uk/id/eprint/11626

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