Effects of acute consumption of fruit and vegetable puree-based drinks on vasodilation and oxidative status

George, Trevor, Waroonphan, Saran, Niwat, Chutamat, Gordon, Mchael and Lovegrove, Julie (2013) Effects of acute consumption of fruit and vegetable puree-based drinks on vasodilation and oxidative status. British Journal of Nutrition, 109 (8). pp. 1442-1452. ISSN 0007-1145

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Official URL: http://dx.doi.org/10.1017/S0007114512003315

Abstract

Epidemiological studies indicate that diets rich in fruits and vegetables (F&V) are protective against cardiovascular diseases (CVD). Pureed \&V products retain many beneficial components, including flavonoids, carotenoids, vitamin C and dietary fibres. This study aimed to establish the physiological effects of acute ingestion of F&V puree-based drink (FVPD) on vasodilation, antioxidant status, phytochemical bioavailability and other CVD risk factors. 24 Subjects, aged 30-70 years, completed the randomised, single-blind, controlled, crossover test meal study. Subjects consumed 400 ml FVPD, or fruit-flavoured sugar-matched control, after following a low-flavonoid diet for 5 days. Blood and urine samples were collected throughout the study day and vascular reactivity was assessed at 90-minute intervals using laser Doppler iontophoresis (LDI). FVPD significantly increased plasma vitamin C (P=0.002) and total nitrate/nitrite (P=0.001) concentrations. There was a near significant time by treatment effect on ex vivo LDL oxidation (P=0.068), with a longer lag phase after consuming FVPD. During the 6 hours after juice consumption the antioxidant capacity of plasma increased significantly (P=0.003) and there was a simultaneous increase in plasma and urinary phenolic metabolites (P=0.05). There were significantly lower glucose and insulin peaks after ingestion of FVPD compared with control (P=0.019 and P=0.003) and a trend towards increased endothelium-dependent vasodilation following FVPD consumption (P=0.061). Overall, FVPD consumption significantly increased plasma vitamin C and total nitrate/nitrite concentrations, with a trend towards increased endothelium-dependent vasodilation. Pureed F&V products are useful vehicles for increasing micronutrient status, plasma antioxidant capacity and in vivo NO generation, which may contribute to CVD risk reduction.

Item Type: Article
Additional Information: First published online 28-9-2012.
Uncontrolled Keywords: Juice, flavonoids vascular reactivity, CVD
Subjects: C100 Biology
Department: Faculties > Health and Life Sciences > School of Life Sciences > Applied Sciences
Depositing User: Ellen Cole
Date Deposited: 19 Apr 2013 14:25
Last Modified: 11 Mar 2017 12:55
URI: http://nrl.northumbria.ac.uk/id/eprint/12329

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