Elucidating the unexplained underperformance syndrome in endurance athletes: the Interleukin-6 hypothesis

Robson-Ansley, Paula (2003) Elucidating the unexplained underperformance syndrome in endurance athletes: the Interleukin-6 hypothesis. Sports Medicine, 33 (10). pp. 771-781. ISSN 0112-1642

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Official URL: http://dx.doi.org/10.2165/00007256-200333100-00004

Abstract

The unexplained underperformance syndrome (UPS), previously known as the overtraining syndrome (OTS), has been defined as a persistent decrement in athletic performance capacity despite 2 weeks of relative rest. It has been proposed that UPS may be caused by excessive cytokine release during and following exercise causing a chronic inflammatory state and 'cytokine sickness'. This article extends that hypothesis by proposing that time-dependent sensitisation could provide a model through which the aetiology of UPS may be explained. In this model, the principal abnormal factors in UPS are an increased production of and/or intolerance to interleukin (IL)-6 during exercise. Strategies to attenuate the IL-6 response to exercise that may also reduce an athlete's susceptibility to UPS are proposed.

Item Type: Article
Additional Information: Sole author. Robson-Ansley was invited to present this work at the High Performance Seminars for UK Sport.
Subjects: C600 Sports Science
Department: Faculties > Health and Life Sciences > School of Life Sciences > Sport, Exercise and Rehabilitation
Depositing User: EPrints Services
Date Deposited: 06 Nov 2008 12:33
Last Modified: 10 Aug 2015 11:51
URI: http://nrl.northumbria.ac.uk/id/eprint/1367

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