Lactoferrin: Antimicrobial activity and therapeutic potential

Embleton, Nicholas, Berrington, Janet, McGuire, William, Stewart, Christopher and Cummings, Stephen (2013) Lactoferrin: Antimicrobial activity and therapeutic potential. Seminars in Fetal and Neonatal Medicine, 18 (3). pp. 143-149. ISSN 1744-165X

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Official URL: http://dx.doi.org/10.1016/j.siny.2013.02.001

Abstract

Lactoferrin is a highly conserved protein from an evolutionary perspective, with a wide range of roles related to protection from infection and promotion of nutritional status. Infection, malnutrition and intestinal pathologies are key inter-related problems, represent important threats to survival and are associated with adverse long-term health outcomes after preterm birth. Lactoferrin is available as a commercial extract from bovine milk and offers potential as a therapeutic intervention for preterm infants modulating infections and intestinal pathologies. In this review we explore the structure, direct antimicrobial effects, modification of host immune function and gastrointestinal effects of lactoferrin. Current trial data are reviewed, and research priorities and challenges identified and discussed.

Item Type: Article
Uncontrolled Keywords: lactoferrin, late-onset infection, microbiome, necrotising enterocolitis
Subjects: C700 Molecular Biology, Biophysics and Biochemistry
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: Becky Skoyles
Date Deposited: 04 Oct 2013 13:05
Last Modified: 24 Oct 2017 11:25
URI: http://nrl.northumbria.ac.uk/id/eprint/13706

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