South Asians and coronary disease: is there discordance between effects on incidence and prognosis?

Zaman, Justin, Philipson, Pete, Chen, Ruoling, Farag, Ahmed, Shipley, Martin, Marmot, Michael, Timmis, Adam and Hemingway, Harry (2013) South Asians and coronary disease: is there discordance between effects on incidence and prognosis? Heart, 99 (10). pp. 729-736. ISSN 1355-6037

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Official URL: http://dx.doi.org/10.1136/heartjnl-2012-302925

Abstract

Objective - To determine whether the effect of South Asian ethnicity differs between studies of incidence and prognosis of coronary disease.

Design - Systematic literature review and meta-analysis, and cohort analysis from a national acute coronary syndrome (ACS) registry linked to mortality (National Institute of Cardiovascular Outcomes Research/Myocardial Infarction National Audit Project).

Setting - International for the review, and England and Wales for the cohort analysis.

Patients - The numbers of South Asians included in the meta-analysis were 111 555 (incidence) and 14 531 (prognosis) of whom 8251 were from the ACS cohort.

Main outcome measures - Incidence studies: non-fatal myocardial infarction or fatal coronary heart disease; prognostic studies: mortality; HRs for 1-year all-cause death in ACS cohort.

Results - South Asians had higher incidence of coronary disease compared with white subjects (HR 1.35 95% CI 1.30 to 1.40) based on meta-analysis of nine studies. Among 10 studies on prognosis, South Asians had better prognosis compared with white subjects (HR 0.78 95% CI 0.74 to 0.82). In the ACS cohort, the impact of diabetes (42.4% of South Asians, 16.9% of white subjects) on 1-year mortality was stronger in South Asians than white subjects (age-adjusted HR 1.83 95% CI 1.59 to 2.11 vs 1.53 95% CI 1.49 to 1.57). However, prognosis was better in South Asians even among diabetics, older people and those living in areas of the highest social deprivation.

Conclusions - South Asian ethnicity is associated with higher incidence of coronary disease, but lower mortality once coronary disease is manifest. The dissociation between effects on incidence and prognosis suggests that public health initiatives to reduce inequalities in mortality between South Asian and white populations should focus on primary prevention.

This is a CALIBER study with ClinicalTrials.gov Identifier: NCT01163513.

Item Type: Article
Subjects: B900 Others in Subjects allied to Medicine
G200 Operational Research
G300 Statistics
Department: Faculties > Engineering and Environment > Mathematics and Information Sciences
Depositing User: Ay Okpokam
Date Deposited: 10 Oct 2013 12:14
Last Modified: 10 Aug 2015 11:11
URI: http://nrl.northumbria.ac.uk/id/eprint/13869

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