Global phylogeny of Shigella sonnei strains from limited single nucleotide polymorphisms (SNPs) and development of a rapid and cost-effective SNP-typing scheme for strain identification by high-resolution melting analysis.

Sangal, Vartul, Holt, Kathryn, Yuan, Jianfeng, Brown, Derek, Filliol-Toutain, Ingrid, Weill, François-Xavier, Kim, Dong-Wook, Dias da Silveira, Wanderley, Pickard, Derek, Thomson, Nicholas, Parkhill, Julian and Yu, Jun (2013) Global phylogeny of Shigella sonnei strains from limited single nucleotide polymorphisms (SNPs) and development of a rapid and cost-effective SNP-typing scheme for strain identification by high-resolution melting analysis. Journal of Clinical Microbiology, 51 (1). pp. 303-5. ISSN 0095-1137

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Official URL: http://dx.doi.org/10.1128/JCM.02238-12

Abstract

The current Shigella sonnei pandemic involves geographically associated, multidrug-resistant clones. This study has demonstrated that S. sonnei phylogeny can be accurately defined with limited single nucleotide polymorphisms (SNPs). By typing 6 informative SNPs using a high-resolution melting (HRM) assay, major S. sonnei lineages/sublineages can be identified as defined by whole-genome variation.

Item Type: Article
Subjects: C500 Microbiology
C700 Molecular Biology, Biophysics and Biochemistry
Department: Faculties > Health and Life Sciences > School of Life Sciences > Applied Sciences
Depositing User: Vartul Sangal
Date Deposited: 08 Nov 2013 15:27
Last Modified: 10 Aug 2015 11:32
URI: http://nrl.northumbria.ac.uk/id/eprint/14540

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