A lack of genetic basis for biovar differentiation in clinically important Corynebacterium diphtheriae from whole genome sequencing.

Sangal, Vartul, Burkovski, Andreas, Hunt, Alison, Edwards, Becky, Blom, Jochen and Hoskisson, Paul (2014) A lack of genetic basis for biovar differentiation in clinically important Corynebacterium diphtheriae from whole genome sequencing. Infection, Genetics and Evolution, 21. pp. 54-57. ISSN 1567-1348

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Official URL: http://dx.doi.org/10.1016/j.meegid.2013.10.019

Abstract

The differentiation of clinically important Corynebacterium diphtheriae into specific biovars is complex and phylogenetically unclear. Comparative genomic analyses of 17 strains indicate that the division of C. diphtheriae into different biovars does not correlate with the variation in the gene content in the relevant metabolic categories that are potentially involved in the biovar discrimination. The biochemical separation is also not supported by phylogenetic analyses, suggesting molecular methods of typing C. diphtheriae strains should be adopted much more widely.

Item Type: Article
Additional Information: Available online before print.
Uncontrolled Keywords: Corynebacterium diphtheriae, biovar, genomic comparison, gene contents, SNPs, pseudogenes
Subjects: C400 Genetics
C500 Microbiology
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: Vartul Sangal
Date Deposited: 11 Nov 2013 11:50
Last Modified: 24 Oct 2017 11:25
URI: http://nrl.northumbria.ac.uk/id/eprint/14554

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