A prostate cancer vaccine comprising whole cells secreting IL-7, effective against subcutaneous challenge, requires local GM-CSF for intra-prostatic efficacy

Schroten-Leof, Caroline, de Riddler, Corinna, Reneman, Suzanne, Crezee, Marije, Dalgleish, Angus, Todryk, Stephen, Bangma, Chris and Kraaij, Robert (2009) A prostate cancer vaccine comprising whole cells secreting IL-7, effective against subcutaneous challenge, requires local GM-CSF for intra-prostatic efficacy. Cancer Immunology Immunotherapy, 58 (2). pp. 373-381. ISSN 0340-7004

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Official URL: http://dx.doi.org/10.1007/s00262-008-0560-z

Abstract

A panel of cytokine-secreting RM-9 prostate cancer cells were tested as whole cell vaccines to determine their capacity to evoke an anti-prostate cancer immune response. In our model, vaccines secreting mGM-CSF or mIL-7 resulted in the highest increase in circulating T lymphocytes after vaccination, prolonged survival and, in a proportion of animals, tumor-free survival. Anti-tumor effects were more evident after a subcutaneous RM-9 challenge than after an intraprostatic challenge. However, when the RM-9/mGM-CSF cell line was used as intraprostatic tumor challenge, protection after RM-9/mIL-7 vaccination was restored.

Item Type: Article
Uncontrolled Keywords: immunotherapy, whole cell vaccine, cytokines, prostate cancer, MPR-model
Subjects: A300 Clinical Medicine
Department: Faculties > Health and Life Sciences > School of Life Sciences > Applied Sciences
Depositing User: EPrint Services
Date Deposited: 19 Apr 2010 11:00
Last Modified: 10 Aug 2015 11:45
URI: http://nrl.northumbria.ac.uk/id/eprint/146

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