Antiretroviral Solid Drug Nanoparticles with Enhanced Oral Bioavailability: Production, Characterization, and In Vitro-In Vivo Correlation

McDonald, Tom, Giardiello, Marco, Martin, Philip, Siccardi, Marco, Liptrott, Neill, Smith, Darren, Roberts, Phill, Curley, Paul, Schipani, Alessandro, Khoo, Saye, Long, James, Foster, Alison, Rannard, Steven and Owen, Andrew (2014) Antiretroviral Solid Drug Nanoparticles with Enhanced Oral Bioavailability: Production, Characterization, and In Vitro-In Vivo Correlation. Advanced Healthcare Materials, 3 (3). pp. 400-411. ISSN 21922640

Full text not available from this repository. (Request a copy)
Official URL: http://dx.doi.org/10.1002/adhm.201300280

Abstract

Nanomedicine strategies have produced many commercial products. However, no orally dosed HIV nanomedicines are available clinically to patients. Although nanosuspensions of drug particles have demonstrated many benefits, experimentally achieving >25 wt% of drug relative to stabilizers is highly challenging. In this study, the emulsion-templated freeze-drying technique for nanoparticles formation is applied for the first time to optimize a nanodispersion of the leading non-nucleoside reverse transcriptase inhibitor efavirenz, using clinically acceptable polymers and surfactants. Dry monoliths containing solid drug nanoparticles with extremely high drug loading (70 wt% relative to polymer and surfactant stabilizers) are stable for several months and reconstitute in aqueous media to provide nanodispersions with z-average diameters of 300 nm. The solid drug nanoparticles exhibit reduced cytoxicity and increased in vitro transport through model gut epithelium. In vivo studies confirm bioavailability benefits with an approximately four-fold higher pharmacokinetic exposure after oral administration to rodents, and predictive modeling suggests dose reduction with the new formulation may be possible.

Item Type: Article
Additional Information: Published online before print.
Uncontrolled Keywords: bioavailability, drug nanoparticles, HIV, nanodispersions, pharmacology
Subjects: B200 Pharmacology, Toxicology and Pharmacy
Department: Faculties > Health and Life Sciences > School of Life Sciences > Applied Sciences
Depositing User: Becky Skoyles
Date Deposited: 15 Nov 2013 15:10
Last Modified: 10 Aug 2015 11:28
URI: http://nrl.northumbria.ac.uk/id/eprint/14617

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics


Policies: NRL Policies | NRL University Deposit Policy | NRL Deposit Licence