Simulated games activity vs continuous running exercise: A novel comparison of the glycemic and metabolic responses in T1DM patients

Campbell, Matthew, West, Dan, Bain, Stephen, Kingsley, Michael, Foley, Paul, Kilduff, Liam, Turner, David, Gray, Ben, Stephens, Jeffrey and Bracken, Richard (2015) Simulated games activity vs continuous running exercise: A novel comparison of the glycemic and metabolic responses in T1DM patients. Scandinavian Journal of Medicine & Science in Sports, 25 (2). pp. 216-222. ISSN 0905-7188

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Abstract

To compare the glycemic and metabolic responses to simulated intermittent games activity and continuous running exercise in type 1 diabetes. Nine patients (seven male, two female; 35 ± 4 years; HbA1c 8.1 ± 0.2%/65 ± 2 mmol/mol) treated on a basal-bolus regimen completed two main trials, a continuous treadmill run (CON) or an intermittent running protocol (INT). Patients arrived to the laboratory fasted at ∼ 08:00 h, replicating their usual pre-exercise meal and administering a 50% reduced dose of rapid-acting insulin before exercising. Blood glucose (BG), K+, Na++, pH, triglycerides, serum cortisol and NEFA were measured at baseline and for 60 min post-exercise. Interstitial glucose was measured for a further 23 h under free-living conditions. Following exercise, BG declined under both conditions but was less under INT (INT −1.1 ± 1.4 vs CON −5.3 ± 0.4 mmol/L, P = 0.037), meaning more patients experienced hypoglycemia (BG ≤ 3.5 mmol/L; CON n = 3 vs INT n = 2) but less hyperglycemia (BG ≥ 10.9 mmol/L; CON n = 0 vs INT n = 6) under CON. Blood lactate was significantly greater, and pH lower, with a temporal delay in K+ under INT (P < 0.05). No conditional differences were observed in other measures during this time, or in interstitial glucose concentrations during the remaining 23 h after exercise. Simulated games activity carries a lower risk of early, but not late-onset hypoglycemia than continuous running exercise in type 1 diabetes.

Item Type:	Article
Uncontrolled Keywords:	T1DM, post-exercise hypoglycemia, intermittent running
Subjects:	C600 Sports Science
Department:	Faculties > Health and Life Sciences > Sport, Exercise and Rehabilitation
Depositing User:	Becky Skoyles
Date Deposited:	10 Mar 2014 12:56
Last Modified:	12 Oct 2019 16:26
URI:	http://nrl.northumbria.ac.uk/id/eprint/15667

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