Aging causes a reorganization of cortical and spinal control of posture

Papegaaij, Selma, Taube, Wolfgang, Baudry, Stéphane, Otten, Egbert and Hortobágyi, Tibor (2014) Aging causes a reorganization of cortical and spinal control of posture. Frontiers in Aging Neuroscience, 6. ISSN 1663-4365

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Official URL: http://dx.doi.org/10.3389/fnagi.2014.00028

Abstract

Classical studies in animal preparations suggest a strong role for spinal control of posture. In humans it is now established that the cerebral cortex contributes to postural control of unperturbed and perturbed standing. The age-related degeneration and accompanying functional changes in the brain, reported so far mainly in conjunction with simple manual motor tasks, may also affect the mechanisms that control complex motor tasks involving posture. This review outlines the age-related structural and functional changes at spinal and cortical levels and provides a mechanistic analysis of how such changes may be linked to the behaviorally manifest postural deficits in old adults. The emerging picture is that the age-related reorganization in motor control during voluntary tasks, characterized by differential modulation of spinal reflexes, greater cortical activation and cortical disinhibition, is also present during postural tasks. We discuss the possibility that this reorganization underlies the increased coactivation and dual task interference reported in elderly. Finally, we propose a model for future studies to unravel the structure-function-behavior relations in postural control and aging.

Item Type: Article
Uncontrolled Keywords: postural control, aging, cerebral cortex, fMRI, TMS, neuroplasticity
Subjects: B100 Anatomy, Physiology and Pathology
Department: Faculties > Health and Life Sciences > School of Life Sciences > Applied Sciences
Depositing User: Becky Skoyles
Date Deposited: 27 Mar 2014 08:34
Last Modified: 10 Aug 2015 11:28
URI: http://nrl.northumbria.ac.uk/id/eprint/15957

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