Karabencheva-Christova, Tatyana, Lee, Christian, Black, Gary, Donev, Rossen and Christov, Christo (2014) How does conformational flexibility influence key structural features involved in activation of anaplastic lymphoma kinase? Molecular BioSystems, 10. pp. 1490-1495. ISSN 1742-206X
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Abstract
Anaplastic Lymphoma Kinase (ALK) plays a major role in developing tumor processes and therefore has emerged as a validated therapeutic target. Applying atomistic molecular dynamics simulations on the wild type enzyme and the nine most frequently occurring and clinically important activation mutants we revealed important conformational effects on key interactions responsible for the activation of the enzyme.
| Item Type: | Article |
|---|---|
| Subjects: | C700 Molecular Biology, Biophysics and Biochemistry |
| Department: | Faculties > Health and Life Sciences > Applied Sciences |
| Depositing User: | Becky Skoyles |
| Date Deposited: | 01 Apr 2014 10:25 |
| Last Modified: | 17 Dec 2023 15:03 |
| URI: | https://nrl.northumbria.ac.uk/id/eprint/16034 |
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