How does conformational flexibility influence key structural features involved in activation of anaplastic lymphoma kinase?

Karabencheva-Christova, Tatyana, Lee, Christian, Black, Gary, Donev, Rossen and Christov, Christo (2014) How does conformational flexibility influence key structural features involved in activation of anaplastic lymphoma kinase? Molecular BioSystems, 10. pp. 1490-1495. ISSN 1742-206X

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Official URL: http://dx.doi.org/10.1039/C4MB00141A

Abstract

Anaplastic Lymphoma Kinase (ALK) plays a major role in developing tumor processes and therefore has emerged as a validated therapeutic target. Applying atomistic molecular dynamics simulations on the wild type enzyme and the nine most frequently occurring and clinically important activation mutants we revealed important conformational effects on key interactions responsible for the activation of the enzyme.

Item Type: Article
Subjects: C700 Molecular Biology, Biophysics and Biochemistry
Department: Faculties > Health and Life Sciences > School of Life Sciences > Applied Sciences
Depositing User: Becky Skoyles
Date Deposited: 01 Apr 2014 10:25
Last Modified: 15 May 2017 06:51
URI: http://nrl.northumbria.ac.uk/id/eprint/16034

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