Memantine improves attention and episodic memory in Parkinson's disease dementia and dementia with Lewy bodies

Wesnes, Keith, Aarsland, Dag, Ballard, Clive and Londos, Elisabet (2015) Memantine improves attention and episodic memory in Parkinson's disease dementia and dementia with Lewy bodies. International Journal of Geriatric Psychiatry, 30 (1). pp. 46-54. ISSN 0885-6230

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Official URL: http://dx.doi.org/10.1002/gps.4109

Abstract

Objective - In both dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD), attentional dysfunction is a core clinical feature together with disrupted episodic memory. This study evaluated the cognitive effects of memantine in DLB and PDD using automated tests of attention and episodic memory.

Methods - A randomised double-blind, placebo-controlled, 24-week three centre trial of memantine (20 mg/day) was conducted in which tests of attention (simple and choice reaction time) and word recognition (immediate and delayed) from the CDR System were administered prior to dosing and again at 12 and 24 weeks. Although other results from this study have been published, the data from the CDR System tests were not included and are presented here for the first time.

Results - Data were available for 51 patients (21 DLB and 30 PDD). In both populations, memantine produced statistically significant medium to large effect sized improvements to choice reaction time, immediate and delayed word recognition.

Conclusions - These are the first substantial improvements on cognitive tests of attention and episodic recognition memory identified with memantine in either DLB or PDD.

Item Type: Article
Additional Information: Published online 16-4-14 ahead of print
Uncontrolled Keywords: memantine, dementia with Lewy bodies, Parkinson's disease dementia, attention, episodic memory, CDR System, automated cognitive tests
Subjects: C800 Psychology
Department: Faculties > Health and Life Sciences > Psychology
Depositing User: Becky Skoyles
Date Deposited: 22 Apr 2014 07:52
Last Modified: 24 Oct 2017 11:32
URI: http://nrl.northumbria.ac.uk/id/eprint/16097

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