Nocardichelins A and B, new siderophores from Nocardia strain Acta 3026

Schneider, Kathrin, Rose, Ilona, Vikineswary, Sabaratnam, Jones, Amanda, Goodfellow, Michael, Nicholson, Graeme, Beil, Winfried, Süssmuth, Roderich and Fiedler, Hans-Peter (2007) Nocardichelins A and B, new siderophores from Nocardia strain Acta 3026. Journal of Natural Products, 70 (6). pp. 932-935. ISSN 0163-3864

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Official URL: http://dx.doi.org/10.1021/np060612i

Abstract

An actinomycete, strain Acta 3026, isolated from mangrove soil was characterized and found to belong to the genus Nocardia. The strain produces two new cytotoxic metabolites, nocardichelins A (1) and B (2). Each of the compounds strongly inhibited human cell lines from gastric adenocarcinoma, breast carcinoma, and hepatocellular carcinoma with GI50 values in a low micromolar to nanomolar range. The structural characterization of the compounds was performed by mass spectrometry and NMR spectroscopy. The nocardichelins represent a new group of siderophores that combine the structural elements of mycobactin-type siderophores from mycobacteria and hydroxamate-type siderophores (desferrioxamine B) produced by streptomycetes. The chromazurol S assay, characteristic for iron(III) complexation, was positive, confirming the role as a siderophore.

Item Type: Article
Uncontrolled Keywords: siderophores, nocardia
Subjects: B200 Pharmacology, Toxicology and Pharmacy
B300 Complementary Medicine
Department: Faculties > Health and Life Sciences > School of Life Sciences > Applied Sciences
Depositing User: EPrint Services
Date Deposited: 29 May 2009 14:25
Last Modified: 10 Aug 2015 11:48
URI: http://nrl.northumbria.ac.uk/id/eprint/1637

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