Data-Based Core Genes Screening for Hepatocellular Carcinoma

Hu, Jinyu and Gao, Zhiwei (2014) Data-Based Core Genes Screening for Hepatocellular Carcinoma. In: IEEE 9th Conference on Industrial Electronics and Applications (ICIEA), 9-11 June, 2014, Hangzhou, China.

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Abstract

In terms of the concepts of gene force and gene community network, a novel multi-layer filter is proposed to screen the core genes. Applying the present algorithm to liver cancer microarray data with 3964 genes, the three core genes, composed of iron-related gene HAMP, metal-related metallothionein genes, and tumor proliferation-related GPC3 gene are screened. Based on these core genes, the formation and development mechanism of the HCC and the relationship between the HCC and trace metals, such as copper, iron and zinc, are analyzed and revealed.

Item Type:	Conference or Workshop Item (Poster)
Subjects:	H600 Electronic and Electrical Engineering
Department:	Faculties > Engineering and Environment > Mathematics, Physics and Electrical Engineering
Depositing User:	Dr Zhiwei Gao
Date Deposited:	15 Jul 2014 09:35
Last Modified:	12 Oct 2019 19:20
URI:	http://nrl.northumbria.ac.uk/id/eprint/17196

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