Women with diarrhoea-predominant irritable bowel syndrome show an increased pressure response to 35% carbon dioxide stress challenge

Shufflebotham, Jonathan, Wetherell, Mark, Hince, Dana, Hood, Sean, Lightman, Stafford, Nutt, David, Probert, Christopher and Potokar, John (2009) Women with diarrhoea-predominant irritable bowel syndrome show an increased pressure response to 35% carbon dioxide stress challenge. Stress: The International Journal on the Biology of Stress, 12 (1). pp. 30-36. ISSN 1025-3890

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Official URL: http://dx.doi.org/10.1080/10253890801976926

Abstract

The responses to inhalation of 35% carbon dioxide (CO2) as a stressor were compared in female irritable bowel syndrome (IBS) patients and healthy controls to assess potential differences in cardiovascular, neuroendocrine and behavioural responses to stress. A total of 22 women (12 patients with ROME II defined diarrhoea-predominant IBS and 10 aged-matched controls) were challenged with a single vital capacity breath of 35% CO2 (with 65% oxygen). Beat-to-beat blood pressure and heart rate were recorded prior to, during and after the inhalation. Serum cortisol concentration and behavioural ratings were measured pre- and post-inhalation. A typical pattern of responses to CO2 was observed, characterised by a reduction in heart rate and increases in serum cortisol and anxiogenic symptoms; however, these responses did not differ between groups. Both groups also demonstrated an increase in systolic blood pressure; however, this response was significantly enhanced in IBS patients compared to healthy controls (P < 0.05). These findings demonstrate that females with diarrhoea-predominant IBS have an exaggerated pressor response to 35% CO2 stress challenge, suggesting a more stress-responsive sympathetic nervous system.

Item Type: Article
Subjects: C800 Psychology
C900 Others in Biological Sciences
Department: Faculties > Health and Life Sciences > School of Life Sciences > Psychology
Depositing User: EPrints Services
Date Deposited: 10 May 2010 14:12
Last Modified: 04 Mar 2016 15:37
URI: http://nrl.northumbria.ac.uk/id/eprint/182

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