A randomised crossover trial of post-operative cognitive and psychomotor recovery from benzodiazepine sedation: Effects of reversal with flumazenil over a prolonged recovery period

Girdler, Nick, Fairbrother, Kevin, Lyne, John Peter, Neave, Nick, Scholey, Andrew, Hargaden, Nick, Wesnes, Keith, Engler, Jonathan and Rotherham, Neil (2002) A randomised crossover trial of post-operative cognitive and psychomotor recovery from benzodiazepine sedation: Effects of reversal with flumazenil over a prolonged recovery period. British Dental Journal, 192 (6). pp. 335-339. ISSN 0007-0610

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Official URL: http://dx.doi.org/10.1038/sj.bdj.4801369

Abstract

Objective: To study the post-operative cognitive and psychomotor recovery from midazolam conscious sedation, after reversal with the benzodiazepine antagonist flumazenil over a prolonged recovery period.
Design: A prospective, double-blind, randomised, crossover trial. Setting: Out-patient Sedation Department, Newcastle Dental Hospital and School Method: Eighteen patients, ASA I or II, received midazolam on two separate occasions to undergo equivalent dental treatment Following treatment patients were reversed with intravenous flumazenil or saline [placebo] at alternate appointments. Assessment of mood and cognitive function was undertaken using a highly sensitive and specific computerised battery of cognitive tests administered by telephone. Cognitive and psychomotor tests were administered prior to sedation and every hour for 6 hours post reversal.
Results: Results indicated no significant effect of flumazenil on simple reaction time and choice reaction time but did show a trend of reversing the effects of midazolam on numeric working memory and word recognition. Conclusion: The cognitive and psychomotor effects of the sedation were not fully reversed by flumazenil. Cognitive impairments were still present up to 6 hours post-reversal, despite patients appearing clinically more alert. This has important implications for treatment protocols and discharge instructions.

Item Type: Article
Department: Faculties > Health and Life Sciences > Psychology
Depositing User: Becky Skoyles
Date Deposited: 27 Jan 2015 15:18
Last Modified: 24 Oct 2017 11:36
URI: http://nrl.northumbria.ac.uk/id/eprint/18589

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