Quantitative structure-extraction relationships: A model for supercritical fluid extraction

Kane, Mark, Dean, John, Hitchen, Steven, Tomlinson, William, Tranter, Roy and Dowle, Christopher (1993) Quantitative structure-extraction relationships: A model for supercritical fluid extraction. Analyst, 118 (10). pp. 1261-1264. ISSN 0003-2654

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Official URL: http://dx.doi.org/10.1039/AN9931801261

Abstract

A rapid method for predicting the solubility of an analyte in supercritical carbon dioxide is reported. The method is based on determining the hydrophobic interaction and the solubility parameter from easily obtained constants. The simplicity of the method is demonstrated with respect to a group of substituted benzophenones. Hydrophobicity is derived from log P values as determined by the Hansch-Leo method, whereas the solubility parameter is determined by the method of Fedors. Multilinear regression has indicated a direct correlation between the amount of analyte extracted, expressed as the mole fraction, and the log Pl solubility parameters.

Item Type: Article
Uncontrolled Keywords: hydrophobicity, molecular structure, partition coefficient, solubility parameter, supercritical fluid extraction
Subjects: F100 Chemistry
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: Becky Skoyles
Date Deposited: 18 Feb 2015 09:46
Last Modified: 24 Oct 2017 11:28
URI: http://nrl.northumbria.ac.uk/id/eprint/18610

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