A comparison between solid phase extraction and supercritical fluid extraction for the determination of fluconazole from animal feed

Khundker, Sharmin, Dean, John and Jones, Peter (1995) A comparison between solid phase extraction and supercritical fluid extraction for the determination of fluconazole from animal feed. Journal of Pharmaceutical and Biomedical Analysis, 13 (12). pp. 1441-1447. ISSN 0731-7085

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Official URL: http://dx.doi.org/10.1016/0731-7085(95)01582-5

Abstract

The application of supercritical fluid extraction with carbon dioxide and modified carbon dioxide for the determination of fluconazole from an animal feed was studied. A fractional factorial design approach was used to examine the significant experimental variables for quantitative extraction of fluconazole. Gas chromatography with either flame ionisation or mass selective detection was used for quantitation of the extracts. The results indicated that modifier (methanol) had the greatest effect on the recovery of fluconazole from the animal feed.

Item Type: Article
Uncontrolled Keywords: animal feed; fluconazole; fractional factorial design; gas chromatography; supercritical fluid extraction
Subjects: D700 Agricultural Sciences
F100 Chemistry
Department: Faculties > Health and Life Sciences > School of Life Sciences > Applied Sciences
Depositing User: Becky Skoyles
Date Deposited: 17 Feb 2015 11:44
Last Modified: 03 Mar 2016 11:46
URI: http://nrl.northumbria.ac.uk/id/eprint/18793

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