Desymmetrization of dichloroazaheterocycles

Goodman, Allan, Stanforth, Stephen and Tarbit, Brian (1999) Desymmetrization of dichloroazaheterocycles. Tetrahedron, 55 (52). pp. 15067-15070. ISSN 0040 4020

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Official URL: http://dx.doi.org/10.1016/S0040-4020(99)00961-8

Abstract

3,6-Dichloropyridizine 1a was converted in good yield into its mono-iodo derivative 1b when treated with a mixture of hydriodic acid and sodium iodide. Pure samples of the mono-iodo derivatives 2b, 3b and 4b could not be obtained from their corresponding dichlorinated precursors with these reagents. Compounds 1b and 4b underwent palladium catalysed Suzuki, Sonogashira and other coupling reactions.

Item Type: Article
Subjects: F100 Chemistry
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: Becky Skoyles
Date Deposited: 16 Feb 2015 11:15
Last Modified: 24 Oct 2017 11:28
URI: http://nrl.northumbria.ac.uk/id/eprint/19145

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