A randomised, controlled trial of cognitive and psychomotor recovery from midazolam sedation following reversal with oral flumazenil

Girdler, Nick, Lyne, John Peter, Wallace, R., Neave, Nick, Scholey, Andrew, Wesnes, Keith and Herman, C. (2002) A randomised, controlled trial of cognitive and psychomotor recovery from midazolam sedation following reversal with oral flumazenil. Anaesthesia, 57 (9). pp. 868-876. ISSN 0003-2409

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Abstract

Flumazenil is traditionally administered intravenously to reverse the adverse effects of over sedation with benzodiazepines. The aim of this study was to test postoperative cognitive and psychomotor recovery from midazolam conscious sedation, following reversal with orally administered flumazenil. It was hypothesised that when administered by the oral route, flumazenil may enhance recovery over a prolonged period, thus increasing safety. Eighteen patients requiring intravenous midazolam sedation for dental treatment completed a randomised, double-blind, crossover trial. Following treatment the patients' sedation was reversed using either flumazenil or saline (as placebo), administered orally, on alternate appointments. Assessment of mood and cognitive function were undertaken using ClinPhone.cdr®, a highly sensitive and specific computerised battery of cognitive tests administered by telephone prior to sedation and every hour for seven hours post reversal. Results indicate that within 20 min of administration, oral flumazenil is capable of partially reversing some cognitive and psychomotor impairments but the attentional and stimulus discrimination effects of midazolam sedation still remain.

Item Type:	Article
Uncontrolled Keywords:	Antagonists: benzodiazepine; Hypnotics: benzodiazepines; midazolam; Memory
Subjects:	A900 Others in Medicine and Dentistry C800 Psychology
Department:	Faculties > Health and Life Sciences > Psychology
Depositing User:	Becky Skoyles
Date Deposited:	11 Feb 2015 14:53
Last Modified:	12 Oct 2019 16:27
URI:	http://nrl.northumbria.ac.uk/id/eprint/19407

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