Application of the Z-Corps three-dimensional printing processes using novel material to manufacture bio-scaffold for bone replacement

Hackney, Philip and Pancholi, Ketan (2004) Application of the Z-Corps three-dimensional printing processes using novel material to manufacture bio-scaffold for bone replacement. In: Fifth National Conference on Rapid Design, Prototyping, and Manufacturing. Wiley-Blackwell, Oxford, pp. 53-60. ISBN 978-1860584657

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Abstract

Tissue engineering promises new bone replacement in areas of large defects due to traumatised, damaged or lost bone. One of the bone formation strategies is to construct bio-scaffold, which allows bone reformation, once it is surgically placed in bone-defect. Current issues with manufacturing and designing bio-scaffolds are mechanical strength along with biocompatibility, osteoinductiveness (which allows induction of bone cells), osteoconductiveness (conducive to cell attachment) of materials of the bio-scaffold. This paper explores the combination of biomaterials to form bio-scaffold using 3D Printing rapid prototyping method. Using novel medical application of synthetic Hydroxyapatite with Sol (hydrolyzed ethyl silicate) to form three-dimensional prototypes, the possibility of bio-scaffold manufacturing for hard tissue engineering is studied. Sintered 3D Printed prototypes are assessed for densification (pore size) and strength using bi-axial stress methodology. Osteoinductiveness and osteoconductiveness of both materials with strong binding tendency of Sol-gel seemed more promising in bio-scaffold manufacturing for bone tissue engineering. Conventional 3D Printing methodology and materials are identified to make bio-scaffold structures. Relationships with temperature and catalyst concentration are studied to use these as basic principles for modification of the 3D Printing process.

Item Type: Book Section
Uncontrolled Keywords: 3D Printing, bio-scaffold, bone tissue engineering, ceramics and porosity, sol
Subjects: H700 Production and Manufacturing Engineering
Department: Faculties > Engineering and Environment > Mechanical and Construction Engineering
Depositing User: Becky Skoyles
Date Deposited: 05 Feb 2015 11:00
Last Modified: 10 Nov 2016 12:17
URI: http://nrl.northumbria.ac.uk/id/eprint/19711

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