Synthesis and testing of chromogenic phenoxazinone substrates for β-alanyl aminopeptidase

Zaytsev, Andrey, Anderson, Rosaleen, Bedernjak, Alexandre, Groundwater, Paul, Huang, Yongxue, Perry, John, Orenga, Sylvain, Roger-Dalbert, Céline and James, Arthur (2008) Synthesis and testing of chromogenic phenoxazinone substrates for β-alanyl aminopeptidase. Organic & Biomolecular Chemistry, 6 (4). pp. 682-692. ISSN 1477-0520

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Official URL: http://dx.doi.org/10.1039/b716978g

Abstract

Novel 7-N-(β-alanyl)aminophenoxazin-3-one salts 27a-d have been synthesized and tested as chromogenic substrates for β-alanyl aminopeptidase, which is present in Pseudomonas aeruginosa, the most common respiratory pathogen in patients with cystic fibrosis. The biological results show that 7-N-(β-alanyl)amino-1-pentylphenoxazin-3-one trifluoroacetate salt 27a is a chromogenic substrate for this bacterium, with a low degree of diffusion in nutrient media for growing bacterial cultures and a bright red colour, making it easily distinguishable from the agar background.

Item Type: Article
Subjects: F100 Chemistry
Department: Faculties > Health and Life Sciences > School of Life Sciences > Applied Sciences
Depositing User: Becky Skoyles
Date Deposited: 27 Jan 2015 17:38
Last Modified: 31 Mar 2016 13:21
URI: http://nrl.northumbria.ac.uk/id/eprint/20235

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