Elloxazinones A and B, new aminophenoxazinones from Streptomyces griseus Acta 2871

Graf, Ellen, Schneider, Kathrin, Nicholson, Graeme, Ströbele, Markus, Jones, Amanda, Goodfellow, Michael, Beil, Winfried, Süssmuth, Roderich and Fiedler, Hans-Peter (2007) Elloxazinones A and B, new aminophenoxazinones from Streptomyces griseus Acta 2871. Journal of Antibiotics, 60. pp. 277-284. ISSN 0021-8820

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Official URL: http://dx.doi.org/10.1038/ja.2007.35

Abstract

Two new aminophenoxazinone compounds with antitumor activity, elloxazinone A and B, were isolated from the culture filtrate of Streptomyces griseus Acta 2871. Their chemical structures were determined by mass spectrometry, NMR spectroscopy and X-ray analysis. Elloxazinones A and B showed a moderate inhibition of the proliferation of human cells from gastric adenocarcinoma in vitro but a strong inhibition of hepatocellular carcinoma cells whereas elloxazinone B strongly inhibited the proliferation of human breast carcinoma cells.

Item Type: Article
Subjects: A100 Pre-clinical Medicine
C700 Molecular Biology, Biophysics and Biochemistry
Department: Faculties > Health and Life Sciences > School of Life Sciences > Applied Sciences
Depositing User: EPrint Services
Date Deposited: 29 May 2009 13:38
Last Modified: 16 Mar 2016 14:11
URI: http://nrl.northumbria.ac.uk/id/eprint/2050

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