Neurogenic mechanisms in bladder and bowel ageing

Ranson, Richard and Saffrey, Jill (2015) Neurogenic mechanisms in bladder and bowel ageing. Biogerontology, 16 (2). pp. 265-284. ISSN 1389-5729

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Official URL: http://dx.doi.org/10.1007/s10522-015-9554-3

Abstract

The prevalence of both urinary and faecal incontinence, and also chronic constipation, increases with ageing and these conditions have a major impact on the quality of life of the elderly. Management of bladder and bowel dysfunction in the elderly is currently far from ideal and also carries a significant financial burden. Understanding how these changes occur is thus a major priority in biogerontology. The functions of the bladder and terminal bowel are regulated by complex neuronal networks. In particular neurons of the spinal cord and peripheral ganglia play a key role in regulating micturition and defaecation reflexes as well as promoting continence. In this review we discuss the evidence for ageing-induced neuronal dysfunction that might predispose to neurogenic forms of incontinence in the elderly.

Item Type: Article
Additional Information: Published online 11-2-2015 ahead of print
Uncontrolled Keywords: Ageing, Bladder, Bowel, Anal sphincter, Incontinence, Constipation, Autonomic nervous system, Enteric nervous system
Subjects: B100 Anatomy, Physiology and Pathology
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: Becky Skoyles
Date Deposited: 03 Mar 2015 09:54
Last Modified: 06 Nov 2017 18:40
URI: http://nrl.northumbria.ac.uk/id/eprint/21506

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