Gene synteny in species of Plasmodium

Carlton, Jane, Vinkenoog, Rinke, Waters, Andrew and Walliker, David (1998) Gene synteny in species of Plasmodium. Molecular and Biochemical Parasitology, 93 (2). pp. 285-294. ISSN 0166 6851

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Official URL: http://dx.doi.org/10.1016/S0166-6851(98)00043-7

Abstract

We have attempted to establish the degree of linkage conservation between different species of the malaria parasite Plasmodium. Initially, the chromosome locations of 42 homologous genes were established in parasites from a rodent malaria species and the human malaria parasite P. falciparum. Of these genes, 26 appeared to be conserved within ten synteny groups between the two genomes. Several synteny groups were analysed further by long-range restriction mapping of digested chromosomes. Finally, a fine restriction map of one of the linkage groups was made from the rodent malaria parasites P. berghei and from P. falciparum and from the simian malaria parasite P. knowlesi. The fine-scale organisation of this linkage group appears to have remained intact among the three species, despite the evolutionary distance between them. This provides the first example of linkage conservation between the rodent, simian and human malaria species, which represent three different branches of the inferred phylogenetic tree of the genus Plasmodium.

Item Type: Article
Subjects: C100 Biology
C400 Genetics
Department: Faculties > Health and Life Sciences > School of Life Sciences > Applied Sciences
Depositing User: Becky Skoyles
Date Deposited: 09 Apr 2015 14:48
Last Modified: 10 Aug 2015 11:52
URI: http://nrl.northumbria.ac.uk/id/eprint/22015

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