Vaccination of horses against strangles using recombinant antigens from Streptococcus equi.

Waller, Andrew, Flock, Margareta, Robinson, Carl, Smith, Ken, Mitchell, Zoe, Karlstrom, Åsa, Lannergard, Jonas, Bergman, Rune, Guss, Bengt and Flock, Jan-Ingmar (2007) Vaccination of horses against strangles using recombinant antigens from Streptococcus equi. Vaccine, 25 (18). pp. 3629-3635. ISSN 0264-410X

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Official URL: http://dx.doi.org/10.1016/j.vaccine.2007.01.060

Abstract

Strangles is an upper respiratory tract infection in horses, which is highly contagious and one of the more costly diseases of the horse. Three recombinant antigens were used to vaccinate horses, which were then experimentally challenged with Streptococcus equi, the causative agent for strangles. The vaccinated horses showed significantly reduced bacterial growth (p = 0.02) and nasal discharge (p = 0.0004), a typical symptom of strangles. Other clinical signs of strangles were also reduced and at post mortem examination, lower rate of empyaema or scarring of the guttural pouches was found in the vaccinated group (p = 0.01). The antigens used were EAG (α2-macroglobulin, albumin, and IgG-binding protein), CNE (a collagen-binding protein), and SclC (a collagen-like protein). The adjuvant used was Abisco, a saponin derived matrix. No adverse effects were observed following vaccination with the antigens and adjuvant.

Item Type: Article
Additional Information: This work, an important collaboration between Prof Waller and a major research group in this field, is an important step towards vaccine development for equine strangles and was dependent on Prof Waller’s work in the Allen Centre for Animal Studies at the Animal Health Trust.
Uncontrolled Keywords: Strangles-Vaccination, Streptococcus equi
Subjects: D200 Clinical Veterinary Medicine and Dentistry
Department: Faculties > Health and Life Sciences > School of Life Sciences > Applied Sciences
Depositing User: EPrint Services
Date Deposited: 08 Jan 2009 12:40
Last Modified: 10 Aug 2015 11:47
URI: http://nrl.northumbria.ac.uk/id/eprint/230

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