Are urinary polyaromatic hydrocarbons associated with adult hypertension, heart attack, and cancer? USA NHANES, 2011-2012

Shiue, Ivy (2015) Are urinary polyaromatic hydrocarbons associated with adult hypertension, heart attack, and cancer? USA NHANES, 2011-2012. Environmental Science and Pollution Research, 22 (21). pp. 16962-16968. ISSN 1614-7499

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Official URL: http://dx.doi.org/10.1007/s11356-015-4922-8

Abstract

Links between environmental chemicals and human health have emerged over the last few decades, but the effects from polyaromatic hydrocarbons were less studied, compared to other commonly known environmental chemicals such as heavy metals, phthalates, arsenic, phenols and pesticides. Therefore, it was aimed to study the relationships of urinary polyaromatic hydrocarbons and adult cardiovascular disease and cancer using human sample in a national and population-based study in recent years. Data was retrieved from US National Health and Nutrition Examination Surveys, 2011-2012, including demographics, self-reported health conditions and urinary polyaromatic hydrocarbons. Statistical analyses included chi-square test, t test, survey-weighted logistic regression modeling and population attributable risk (PAR) estimation. Of 5560 American adults aged 20-80 and included in the statistical analysis, urinary polyaromatic hydrocarbons (representatively in one-third sample) were observed to be higher in people with cardiovascular disease and total cancer. In particular, urinary 4-hydroxyphenanthrene was associated with hypertension (odds ratio (OR) 1.33, 95 % confidence interval (CI) 1.00-1.76, P = 0.048, PAR 5.1 %), urinary 1-hydroxypyrene was significantly associated with heart attack (OR 1.47, 95 %CI 1.05-2.06, P = 0.027, PAR 1.7 %), and urinary 2-hydroxynapthalene (2-naphthol) was associated with cancer (OR 1.46, 95 %CI 1.12-1.90, P = 0.008, PAR 3.9 %). Urinary polyaromatic hydrocarbons were associated with adult hypertension, heart attack and cancer, although the causality cannot be established. From the research perspective, future studies with a longitudinal or experimental approach would be suggested. From the law and public health perspectives, regulation on minimizing exposure to polyaromatic hydrocarbons might need to be considered in future health and environmental policies and intervention programs.

Item Type: Article
Additional Information: published online ahead of print
Uncontrolled Keywords: Polyaromatic hydrocarbons, risk factor, hypertension, heart attack, cancer, angina
Subjects: B200 Pharmacology, Toxicology and Pharmacy
Department: Faculties > Health and Life Sciences > School of Health, Community and Education Studies > Nursing, Midwifery and Health
Depositing User: Nicola King
Date Deposited: 06 Jul 2015 08:44
Last Modified: 03 Feb 2016 14:54
URI: http://nrl.northumbria.ac.uk/id/eprint/23210

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