Alterations in whole-body insulin sensitivity resulting from repeated eccentric exercise of a single muscle group: a pilot investigation

Gonzalez, Javier, Barwood, Martin, Goodall, Stuart, Thomas, Kevin and Howatson, Glyn (2015) Alterations in whole-body insulin sensitivity resulting from repeated eccentric exercise of a single muscle group: a pilot investigation. International Journal of Sport Nutrition and Exercise Metabolism, 25 (4). pp. 405-410. ISSN 1526-484X

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Official URL: http://dx.doi.org/10.1123/ijsnem.2014-0211

Abstract

Unaccustomed eccentric exercise using large muscle groups elicits soreness, decrements in physical function and impairs markers of whole-body insulin sensitivity; although these effects are attenuated with a repeated exposure. Eccentric exercise of a small muscle group (elbow flexors) displays similar soreness and damage profiles in response to repeated exposure. However, it is unknown whether damage to small muscle groups impacts upon whole-body insulin sensitivity. This pilot investigation aimed to characterize whole-body insulin sensitivity in response to repeated bouts of eccentric exercise of the elbow flexors. Nine healthy males completed two bouts of eccentric exercise separated by 2 weeks. Insulin resistance (updated homeostasis model of insulin resistance, HOMA2-IR) and muscle damage profiles (soreness and physical function) were assessed before, and 48 h after exercise. Matsuda insulin sensitivity indices (ISIMatsuda) were also determined in 6 participants at the same time points as HOMA2-IR. Soreness was elevated, and physical function impaired, by both bouts of exercise (both P < 0.05) but to a lesser extent following bout 2 (time x bout interaction, P < 0.05). Eccentric exercise decreased ISIMatsuda after the first but not the second bout of eccentric exercise (time x bout interaction P < 0.05). Eccentric exercise performed with an isolated upper limb impairs whole-body insulin sensitivity after the first, but not the second, bout.

Item Type: Article
Additional Information: © 2015 Human Kinetics, Inc. As accepted for publication
Uncontrolled Keywords: glucose, glycemia, insulin resistance, metabolic control, muscle damage, repeated bout
Subjects: C600 Sports Science
Department: Faculties > Health and Life Sciences > School of Life Sciences > Sport, Exercise and Rehabilitation
Depositing User: Glyn Howatson
Date Deposited: 03 Jul 2015 08:11
Last Modified: 18 May 2017 02:01
URI: http://nrl.northumbria.ac.uk/id/eprint/23232

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