Structures of two truncated phage-tail hyaluronate lyases from Streptococcus pyogenes serotype M1

Martinez-Fleites, C., Smith, Nicola L., Turkenburg, Johan, Black, Gary and Taylor, Edward (2009) Structures of two truncated phage-tail hyaluronate lyases from Streptococcus pyogenes serotype M1. Acta Crystallographica, Section F: Structural Biology and Crystallization Communications, 65 (10). pp. 963-966. ISSN 1744-3091

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Official URL: http://dx.doi.org/10.1107/S1744309109032813

Abstract

The crystal structures of truncated forms of the Streptococcus pyogenes phage-encoded hyaluronate lyases HylP2 and HylP3 were determined by molecular replacement to 1.6 and 1.9 Å resolution, respectively. The truncated forms crystallized in a hexagonal space group, forming a trimer around the threefold crystallographic axis. The arrangement of the fold is very similar to that observed in the structure of the related hyaluronate lyase HylP1. The structural elements putatively involved in substrate recognition are found to be conserved in both the HylP2 and HylP3 fragments.

Item Type: Article
Uncontrolled Keywords: carbohydrates, lyases, streptococci, bacteriophages.
Subjects: A100 Pre-clinical Medicine
C900 Others in Biological Sciences
Department: Faculties > Health and Life Sciences > School of Life Sciences > Applied Sciences
Depositing User: EPrint Services
Date Deposited: 29 Jan 2010 15:58
Last Modified: 10 Aug 2015 11:45
URI: http://nrl.northumbria.ac.uk/id/eprint/2333

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