Effects of upper-limb exercise on lower-limb cutaneous microvascular function in post-surgical varicose-vein patients

Klonizakis, Markos, Tew, Garry, Michaels, Jonathan and Saxton, John (2010) Effects of upper-limb exercise on lower-limb cutaneous microvascular function in post-surgical varicose-vein patients. European Journal of Applied Physiology, 109 (6). pp. 1221-1224. ISSN 1439-6319

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Official URL: http://dx.doi.org/10.1007/s00421-010-1471-1

Abstract

Regular walking exercise attenuates lower-limb cutaneous microvascular endothelial dysfunction in post-surgical varicose-vein patients. This study assessed the effects of upper-limb exercise training on lower-limb cutaneous microvascular function in this patient group. Six post-surgical (4–5 weeks) varicose-vein patients completed an 8-week arm-crank exercise training programme. Changes in cutaneous microvascular function of the lower leg were assessed using laser Doppler flowmetry and iontophoretic administration of endothelial-dependent and -independent agonists [acetylcholine (ACh) and sodium nitroprusside (SNP), respectively]. At 8 weeks, median lower-limb cutaneous vasodilator responsives to ACh and SNP remained unchanged relative to baseline (e.g. 6 mC: 37 (interquartile range 24–63) vs. 40 (20–71) PU and 35 (23–48) vs. 38 (21–64) PU, respectively for the supine position). Upper-limb exercise appears ineffective for improving lower-limb cutaneous microvascular function in post-surgical varicose-vein patients. Therefore, limb specificity appears an important factor in optimal exercise prescription for these patients.

Item Type: Article
Subjects: A300 Clinical Medicine
B100 Anatomy, Physiology and Pathology
C600 Sports Science
Department: Faculties > Health and Life Sciences > Sport, Exercise and Rehabilitation
Depositing User: Garry Tew
Date Deposited: 04 Aug 2015 15:38
Last Modified: 24 Oct 2017 14:20
URI: http://nrl.northumbria.ac.uk/id/eprint/23511

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