Rethinking the old antiviral drug moroxydine: Discovery of novel analogues as anti-hepatitis C virus (HCV) agents

Magri, Andrea, Reilly, Roisin, Scalacci, Nicolò, Radi, Marco, Hunter, Michael, Ripoll, Manon, Patel, Arvind H. and Castagnolo, Daniele (2015) Rethinking the old antiviral drug moroxydine: Discovery of novel analogues as anti-hepatitis C virus (HCV) agents. Bioorganic & Medicinal Chemistry Letters, 25 (22). pp. 5372-5376. ISSN 0960-894X

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Official URL: http://dx.doi.org/10.1016/j.bmcl.2015.09.029

Abstract

The discovery of a novel class of HCV inhibitors is described. The new amidinourea compounds were designed as isosteric analogues of the antiviral drug moroxydine. The two derivatives 11g and 11h showed excellent HCV inhibition activity and viability and proved to inhibit a step(s) of the RNA replication. The new compounds have been synthesized in only three synthetic steps from cheap building blocks and in high yields, thus turning to be promising drug candidates in the development of cheaper HCV treatments.

Item Type: Article
Uncontrolled Keywords: HCV, Amidinourea, Guanidine, Hepatitis C life cycle, RNA replication
Subjects: C700 Molecular Biology, Biophysics and Biochemistry
Department: Faculties > Health and Life Sciences > School of Life Sciences > Applied Sciences
Depositing User: Paul Burns
Date Deposited: 18 Nov 2015 10:19
Last Modified: 03 Nov 2016 13:08
URI: http://nrl.northumbria.ac.uk/id/eprint/24531

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