Lipoprotein biogenesis in gram-positive bacteria: knowing when to hold 'em, knowing when to fold 'em

Hutchings, Matthew, Palmer, Tracy, Harrington, Dean and Sutcliffe, Iain (2009) Lipoprotein biogenesis in gram-positive bacteria: knowing when to hold 'em, knowing when to fold 'em. Trends in Microbiology, 17 (1). pp. 13-21. ISSN 0966-842X

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Official URL: http://dx.doi.org/10.1016/j.tim.2008.10.001

Abstract

Gram-positive bacterial lipoproteins are a functionally diverse and important class of peripheral membrane proteins. Recent advances in molecular biology and the availability of whole genome sequence data have overturned many long-held assumptions about the export and processing of these proteins, most notably the recent discovery that not all lipoproteins are exported as unfolded substrates through the general secretion pathway. Here, we review recent discoveries concerning the export and processing of these proteins, their role in virulence in Gram-positive bacteria and their potential as vaccine candidates or targets for new anti-microbials.

Item Type: Article
Subjects: F100 Chemistry
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: EPrint Services
Date Deposited: 26 Feb 2010 13:27
Last Modified: 24 Oct 2017 11:26
URI: http://nrl.northumbria.ac.uk/id/eprint/2456

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