MicroRNAs in fibrosis: opportunities and challenges

O'Reilly, Steven (2016) MicroRNAs in fibrosis: opportunities and challenges. Arthritis Research & Therapy, 18 (1). ISSN 1478-6362

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Official URL: http://dx.doi.org/10.1186/s13075-016-0929-x

Abstract

MicroRNAs (miRNAs) are small, non-coding RNAs that mediate mRNA cleavage, translational repression or mRNA destabilisation and are around 22-25 nucleotides in length via partial complementary binding to the 3' untranslated region in target transcripts. They are master regulators of gene expression. Fibrosis is an important cause of morbidity and mortality in the world, and there are currently no accepted treatments for fibrosis. Many novel miRNAs are now associated with fibrosis, both organ-specific and systemic, as in the prototypical fibrotic disease systemic sclerosis. Recently, the targets of these altered miRNAs have been validated and defined new biochemical pathways. Dysregulated miRNAs are amenable to therapeutic modulation. This review will examine the role of miRNAs in fibrosis and the opportunities and challenges of targeting them.

Item Type: Article
Additional Information: No funder data supplied.
Subjects: C400 Genetics
C700 Molecular Biology, Biophysics and Biochemistry
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: Paul Burns
Date Deposited: 27 Jan 2016 16:45
Last Modified: 01 Nov 2017 19:59
URI: http://nrl.northumbria.ac.uk/id/eprint/25730

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