Differences in memory function between 5-HT1A receptor genotypes in patients with major depressive disorder

Wesnes, Keith, Hopkins, Seth, Brooker, Helen and Koblan, Kenneth (2016) Differences in memory function between 5-HT1A receptor genotypes in patients with major depressive disorder. CNS Spectrums, 21 (5). pp. 379-384. ISSN 1092-8529

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Official URL: http://dx.doi.org/10.1017/S1092852915000802

Abstract

Background:
While extensive literature on the role of the serotonin receptor 1A (5-HT1A-R) in cognition exists, the findings are largely from animal studies. There has been little research conducted into 5-HT1A-R genotypes and cognitive function in humans. This article evaluates the role of 5-HT1A-R genotypes on the profile of cognitive function in patients with major depressive disorder (MDD).

Methods:
The study sample was 455 MDD patients aged between 18 and 55 years. They had enrolled into a clinical trial and were tested prior to dosing on the baseline study day using the CDR System, an integrated set of 3 attention tests, 2 working memory tests, and 4 episodic memory tests. 5-HT1A-R genotyping for (SNP ID rs6295) had been conducted during the study screening period.

Results:
Validated factor scores were derived from the 9 tests. It was found that patients with the C/C genotype for the C(1019)G polymorphism of the 5-HT1A-R were significantly superior in retaining and retrieving information, in both working and episodic memory, than those with either the C/G or the G/G genotypes. No differences were found in measures of attention or in the speed of retrieval of information from memory.

Conclusions:
This is, to our knowledge, the first relationship found between objective tests of cognitive function and 5-HT1A-R genotypes in MDD.

Item Type: Article
Uncontrolled Keywords: 5-HT1A-R; cognitive function; CDR System; genotypes; MDD; memory
Subjects: C400 Genetics
C800 Psychology
Department: Faculties > Health and Life Sciences > Psychology
Depositing User: Paul Burns
Date Deposited: 03 Feb 2016 11:45
Last Modified: 24 Oct 2017 11:31
URI: http://nrl.northumbria.ac.uk/id/eprint/25834

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