Urinary polyaromatic hydrocarbons are associated with adult celiac disease and kidney stones: USA NHANES, 2011–2012

Shiue, Ivy (2016) Urinary polyaromatic hydrocarbons are associated with adult celiac disease and kidney stones: USA NHANES, 2011–2012. Environmental Science and Pollution Research, 23 (4). pp. 3971-3977. ISSN 0944-1344

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Official URL: http://dx.doi.org/10.1007/s11356-015-5980-7

Abstract

Links between environmental chemicals and human health have emerged over the last few decades, but the effects from polyaromatic hydrocarbons (PAH) were less studied, compared to other commonly known environmental chemicals such as heavy metals, phthalates, arsenic, phenols, and pesticides. Therefore, it was aimed to study the relationships of urinary PAH and adult digestive conditions using a large human sample in a national and population-based study in recent years. Data was retrieved from the US National Health and Nutrition Examination Surveys, 2011–2012 including demographics, self-reported health conditions, and urinary PAH. Statistical analyses included chi-square test, t test, survey-weighted logistic regression modeling, and population attributable risk (PAR) estimation. Of 5560 American adults aged 20–80 and included in the statistical analysis, urinary 4-hydroxyphenanthrene was significantly associated with celiac disease (odds ratio (OR) 1.61, 95 % confidence interval (CI) 1.14–2.26, P = 0.009). In addition, urinary 2-hydroxyfluorene (OR 1.35, 95 % CI 1.02–1.78, P = 0.038), 3-hydroxyfluorene (OR 1.35, 95 % CI 1.07–1.70, P = 0.015), 1-hydroxyphenanthrene (OR 1.48, 95 % CI 1.08–2.03, P = 0.017), 1-hydroxypyrene (OR 1.36, 95 % CI 1.05–1.77, P = 0.023), and 2-hydroxynapthalene (OR 1.25, 95 % CI 1.00–1.58, P = 0.054) were significantly associated with kidney stones, although not necessarily failing kidney. There were no statistically significant associations observed in the relationship of urinary PAH and liver problems, although higher levels of PAHs were observed. Urinary PAHs are associated with adult digestive conditions, although the causality cannot be established. From the research perspective, longitudinal monitoring from observational studies and experimental research understanding mechanism would be suggested. Regulation of minimizing PAHs exposure might need to be considered in future health and environmental policies.

Item Type: Article
Uncontrolled Keywords: Polyaromatic hydrocarbons, Risk factor, Kidney, Celiac disease, Environmental health, Risk assessment
Subjects: B900 Others in Subjects allied to Medicine
F800 Physical and Terrestrial Geographical and Environmental Sciences
Department: Faculties > Health and Life Sciences > School of Health, Community and Education Studies > Nursing, Midwifery and Health
Depositing User: Becky Skoyles
Date Deposited: 26 Feb 2016 14:14
Last Modified: 15 May 2017 19:30
URI: http://nrl.northumbria.ac.uk/id/eprint/26167

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