Pragmatic intervention for increasing self-directed exercise behaviour and improving important health outcomes in people with multiple sclerosis: a randomised controlled trial

Carter, Anouska, Daley, Amanda, Humphreys, Liam, Snowdon, Nicky, Woodroofe, Nicola, Petty, Jane, Roalfe, Andrea, Tosh, Jonathan, Sharrack, Basil and Saxton, John (2014) Pragmatic intervention for increasing self-directed exercise behaviour and improving important health outcomes in people with multiple sclerosis: a randomised controlled trial. Multiple Sclerosis, 20 (8). pp. 1112-1122. ISSN 1352-4585

[img]
Preview
Text
Carterpragmatic intervention.pdf - Accepted Version

Download (1MB) | Preview
Official URL: http://dx.doi.org/10.1177/1352458513519354

Abstract

Background - Exercise programmes that can demonstrate evidence of long-lasting clinical effectiveness are needed for people with multiple sclerosis (PwMS).

Objective - The objective of this study was to assess the effects of a practically implemented exercise programme on self-directed exercise behaviour and important health outcomes in PwMS to nine months of follow-up.

Methods - We conducted a parallel-arm, randomised controlled trial: 120 PwMS (Expanded Disability Status Scale (EDSS) 1.0-6.5) randomised to a three-month exercise intervention plus usual care, or usual care only. Two supervised plus one home-exercise session (weeks 1-6) were followed by one supervised and two home-exercise sessions (weeks 7-12). Cognitive-behavioural techniques promoted long-term exercise behaviour change. Outcomes were blindly assessed at baseline and at three and nine months after randomisation. The primary outcome was self-reported exercise behaviour (Godin Leisure Time Exercise Questionnaire (GLTEQ)). Secondary outcomes included fatigue and health-related quality of life (HRQoL).

Results - The intervention increased self-reported exercise (9.6 points; 95% CI: 2.0 to 17.3 points; p = 0.01) and improved fatigue (p < 0.0001) and many HRQoL domains (p ≤ 0.03) at three months. The improvements in emotional well-being (p = 0.01), social function (p = 0.004) and overall quality of life (p = 0.001) were sustained for nine months.

Conclusion - This pragmatic approach to implementing exercise increases self-reported exercise behaviour, improves fatigue and leads to a sustained enhancement of HRQoL domains in PwMS.

Item Type: Article
Uncontrolled Keywords: Pragmatic exercise, cognitive behavioural, fatigue, health-related quality of life
Subjects: B100 Anatomy, Physiology and Pathology
Department: Faculties > Health and Life Sciences > School of Life Sciences > Sport, Exercise and Rehabilitation
Depositing User: John Saxton
Date Deposited: 01 Mar 2016 10:13
Last Modified: 08 May 2017 23:32
URI: http://nrl.northumbria.ac.uk/id/eprint/26197

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics


Policies: NRL Policies | NRL University Deposit Policy | NRL Deposit Licence