Lifestyle intervention in men with advanced prostate cancer receiving androgen suppression therapy: a feasibility study.

Bourke, Liam, Doll, Helen, Crank, Helen, Daley, Amanda, Rosario, Derek J. and Saxton, John (2011) Lifestyle intervention in men with advanced prostate cancer receiving androgen suppression therapy: a feasibility study. Cancer Epidemiology, Biomarkers and Prevention, 20 (4). pp. 647-57. ISSN 1538-7755

Full text not available from this repository.
Official URL: http://dx.doi.org/10.1158/1055-9965.EPI-10-1143

Abstract

BACKGROUND

Healthy lifestyle behaviors could have a role in ameliorating some of the adverse effects of androgen suppression therapy (AST) in men with prostate cancer. The primary aim of this study was to assess the feasibility of a tapered supervised exercise program in combination with dietary advice in men with advanced prostate cancer receiving AST.

METHODS

Advanced prostate cancer patients receiving AST for a minimum of 6 months were randomized to a 12-week lifestyle program comprising aerobic and resistance exercise, plus dietary advice (n = 25), or standard care (n = 25). Exercise behavior, dietary macronutrient intake, quality of life, fatigue, functional fitness, and biomarkers associated with disease progression were assessed at baseline, after the intervention, and at 6 months.

RESULTS

The lifestyle group showed improvements in exercise behavior (P < 0.001), dietary fat intake (P = 0.001), total energy intake (P = 0.005), fatigue (P = 0.002), aerobic exercise tolerance (P < 0.001), and muscle strength (P = 0.033) compared with standard care controls. Although a high rate of attrition (44%) was observed at 6 months, the improvements in key health outcomes were sustained. No effects on clinical prostate cancer disease markers were observed.

CONCLUSIONS

This preliminary evidence suggests that pragmatic lifestyle interventions have potential to evoke improvements in exercise and dietary behavior, in addition to other important health outcomes in men with advanced prostate cancer receiving AST.

IMPACT

This study shows for the first time that pragmatic lifestyle interventions are feasible and could have a positive impact on health behaviors and other key outcomes in men with advanced prostate cancer receiving AST.

Item Type: Article
Subjects: A300 Clinical Medicine
Department: Faculties > Health and Life Sciences > School of Life Sciences > Sport, Exercise and Rehabilitation
Depositing User: John Saxton
Date Deposited: 01 Mar 2016 11:41
Last Modified: 17 Mar 2016 12:28
URI: http://nrl.northumbria.ac.uk/id/eprint/26212

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