The effect of desvenlafaxine on cognitive functioning in employed outpatients with major depressive disorder: A substudy of a randomized, double-blind, placebo-controlled trial

Reddy, Sujana, Fayyad, Rana, Edgar, Chris J., Guico-Pabia, Christine J. and Wesnes, Keith (2016) The effect of desvenlafaxine on cognitive functioning in employed outpatients with major depressive disorder: A substudy of a randomized, double-blind, placebo-controlled trial. Journal of Psychopharmacology, 30 (6). pp. 559-567. ISSN 0269-8811

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Official URL: http://dx.doi.org/10.1177/0269881116631649

Abstract

The objective of this substudy was to examine the effect of desvenlafaxine 50 mg/day compared with placebo on cognitive function in employed outpatients with major depressive disorder. A total of 11/55 (20%) study sites in a 12-week, randomized, double-blind, placebo-controlled trial administered cognitive assessments in memory, attention, and executive functioning domains using the cognitive drug research system. Changes from baseline were subjected to analysis of covariance with baseline levels as covariates, using last observation carried forward data.
A significant improvement with desvenlafaxine 50 mg/day(n=52) compared with placebo (n=29) was observed on the quality of working memory composite measure (0.081 units (0.005, 0.156); P=0.0365) at last observation carried forward. Improvement from baseline on the speed of working memory composite was significant for desvenlafaxine (−226.6 msec (−316.7, −136.4); P<0.0001) and for placebo (−133.3 msec (−257.2, −9.4); P=0.0354); however, the treatment effect was not significant. No significant differences between groups were observed on composite measures for attention. Treatment of depression with desvenlafaxine 50 mg/day may improve aspects of cognitive functioning, including working memory.

Item Type: Article
Uncontrolled Keywords: Desvenlafaxine, major depressive disorder, cognition
Subjects: C800 Psychology
Department: Faculties > Health and Life Sciences > Psychology
Depositing User: Nicola King
Date Deposited: 26 May 2016 14:10
Last Modified: 24 Oct 2017 11:31
URI: http://nrl.northumbria.ac.uk/id/eprint/26960

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