Changes in the substance P-containing innervation of the lumbosacral spinal cord in male Wistar rats as a consequence of ageing

Ranson, Richard, Priestley, David, Santer, Robert and Watson, Alan (2005) Changes in the substance P-containing innervation of the lumbosacral spinal cord in male Wistar rats as a consequence of ageing. Brain Research, 1036 (1-2). pp. 139-144. ISSN 0006-8993

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Official URL: http://dx.doi.org/10.1016/j.brainres.2004.12.031

Abstract

Substance P is implicated in controlling micturition reflexes. This investigation revealed Substance P immunoreactive terminals which markedly declined in spinal regions associated with bladder emptying/storage that were not replicated in regions associated with sphincter control. This observation reinforces concepts of ‘differential susceptibility’ to ageing in terms of axon pathology.

Item Type: Article
Uncontrolled Keywords: dorsolateral nucleus, image analysis, immunocytochemistry, micturition
Subjects: A100 Pre-clinical Medicine
Department: Faculties > Health and Life Sciences > Applied Sciences
Depositing User: EPrint Services
Date Deposited: 06 Jan 2009 09:16
Last Modified: 24 Oct 2017 11:28
URI: http://nrl.northumbria.ac.uk/id/eprint/2742

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