Microwave-assisted domino reactions of propargylamines with isothiocyanates: selective synthesis of 2-aminothiazoles and 2-amino-4-methylenethiazolines

Castagnolo, Daniele, Scalacci, Nicolò, Pelloja, Chiara and Radi, Marco (2016) Microwave-assisted domino reactions of propargylamines with isothiocyanates: selective synthesis of 2-aminothiazoles and 2-amino-4-methylenethiazolines. Synlett, 27 (12). pp. 1883-1887. ISSN 0936-5214

Full text not available from this repository.
Official URL: http://dx.doi.org/10.1055/s-0035-1561985

Abstract

A simple and versatile microwave-assisted protocol for the synthesis of 2-aminothiazoles has been developed. The domino reaction of propargylamines and isothiocyanates in the presence of catalytic PTSA leads to the selective synthesis of 2-aminothiazoles at temperatures above 130 °C and in a few minutes. The same reaction carried out at lower temperatures leads to the formation of the tautomeric 2-amino-4-methylenethiazolines.

Item Type: Article
Subjects: C700 Molecular Biology, Biophysics and Biochemistry
Department: Faculties > Health and Life Sciences > School of Life Sciences > Applied Sciences
Depositing User: Becky Skoyles
Date Deposited: 08 Aug 2016 11:21
Last Modified: 27 Sep 2016 11:55
URI: http://nrl.northumbria.ac.uk/id/eprint/27449

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