Microwave-assisted domino reactions of propargylamines with isothiocyanates: selective synthesis of 2-aminothiazoles and 2-amino-4-methylenethiazolines

Castagnolo, Daniele, Scalacci, Nicolò, Pelloja, Chiara and Radi, Marco (2016) Microwave-assisted domino reactions of propargylamines with isothiocyanates: selective synthesis of 2-aminothiazoles and 2-amino-4-methylenethiazolines. Synlett, 27 (12). pp. 1883-1887. ISSN 0936-5214

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Abstract

A simple and versatile microwave-assisted protocol for the synthesis of 2-aminothiazoles has been developed. The domino reaction of propargylamines and isothiocyanates in the presence of catalytic PTSA leads to the selective synthesis of 2-aminothiazoles at temperatures above 130 °C and in a few minutes. The same reaction carried out at lower temperatures leads to the formation of the tautomeric 2-amino-4-methylenethiazolines.

Item Type:	Article
Subjects:	C700 Molecular Biology, Biophysics and Biochemistry
Department:	Faculties > Health and Life Sciences > Applied Sciences
Depositing User:	Becky Skoyles
Date Deposited:	08 Aug 2016 11:21
Last Modified:	11 Oct 2019 14:31
URI:	http://nrl.northumbria.ac.uk/id/eprint/27449

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