Towards a multidimensional healthy ageing phenotype

Mount, Sarah, Lara, Jose, Schols, Annemie and Mathers, John (2016) Towards a multidimensional healthy ageing phenotype. Current Opinion in Clinical Nutrition and Metabolic Care, 19. pp. 418-426. ISSN 1363-1950

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Official URL: http://dx.doi.org/10.1097/MCO.0000000000000318

Abstract

Purpose of review: There is great interest in developing tools to measure healthy ageing and to identify early stages of health impairment, which may guide the implementation of interventions to prevent or delay the development of disease, disability, and mortality. Here, we review the most recent developments directed to operationalize, and test, definitions of healthy ageing.

Recent findings: There is lack of consensus about how to define healthy ageing and, unsurprisingly, diversity in the instruments for its measurement. However, progress is being made in describing and in devising tools to capture the healthy ageing phenotype. Attempts to measure healthy ageing have relied primarily on cross-sectional data collected in older people. More recent studies have assessed the healthy ageing phenotype using markers of multiple functional domains and have used longitudinal data to model the dynamics and trajectories of healthy ageing.

Summary: Given the complexity of the ageing process, no single measure is able to predict the ageing trajectory. Current attempts to operationalize the healthy ageing phenotype have relied on markers and data from earlier cohort studies and are limited by the tools used to collect data in those studies. Such data are often unsuitable to detect early subtle declines in function and/or are inappropriate for use in younger old adults. Future studies employing more objective and novel markers of healthy ageing are likely to offer opportunities to define and operationalize the healthy ageing phenotype.

Item Type: Article
Uncontrolled Keywords: healthy ageing phenotype, markers, validation
Subjects: B400 Nutrition
B900 Others in Subjects allied to Medicine
Department: Faculties > Health and Life Sciences > School of Life Sciences > Applied Sciences
Depositing User: Becky Skoyles
Date Deposited: 05 Sep 2016 14:06
Last Modified: 10 Sep 2017 16:25
URI: http://nrl.northumbria.ac.uk/id/eprint/27648

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