Relevance of systems pharmacology in drug discovery.

Cucurull-Sanchez, Lourdes, Spink, Karen and Moschos, Sterghios (2012) Relevance of systems pharmacology in drug discovery. Drug Discovery Today, 17 (13-14). pp. 665-670. ISSN 1359-6446

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Official URL: http://dx.doi.org/10.1016/j.drudis.2012.01.015

Abstract

The pharmaceutical industry is in the process of re-inventing its pipeline in an attempt to overcome its increasing phase II and III attrition rates. Here, we describe how systems pharmacology can be used as a risk assessment tool to alleviate this problem before bringing in larger investments. We propose that this translational research tool could provide a valuable, complementary addition to other emerging innovative approaches for target identification and validation in discovery and, ultimately, for aiding clinical trial optimization.

Item Type: Article
Subjects: B200 Pharmacology, Toxicology and Pharmacy
Department: Faculties > Health and Life Sciences > School of Life Sciences > Applied Sciences
Depositing User: Sterghios Moschos
Date Deposited: 24 Oct 2016 13:49
Last Modified: 24 Oct 2016 13:49
URI: http://nrl.northumbria.ac.uk/id/eprint/28135

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